So, a few days ago I was talking with a good friend about a mutual friend and about another friend and that friend's friend's friend and our friend's friend and another friend (or something like that).
And I came up with this:
There is nothing more lonely than a woman who is emotionally, mentally, and spiritually ignored by a man who has promised to cherish her forever.
P.S. And for clarity's sake (and to head off differing branches of debate), let's assume this woman and man are married (or were) and have children (one or many--any age), and practice the same religion.